The diet-heart hypothesis posits that saturated fats, which are found in foods like butter, red meat, and dairy, raise blood cholesterol levels and, as a result, increase the risk of cardiovascular disease (CVD). Early observational studies, such as Keys’ famous Seven Countries Study, suggested a strong correlation between high saturated fat intake and heart disease rates. However, these studies were criticized for their methodological flaws, such as cherry-picking countries that fit the hypothesis and overlooking those that didn’t.
Subsequent clinical trials throughout the 1960s and 1970s tested the hypothesis by replacing saturated fats with polyunsaturated fats (primarily from vegetable oils) in participants' diets. Surprisingly, while these interventions did lower cholesterol levels, they did not result in significant reductions in heart attacks or overall mortality. Despite these results, the diet-heart hypothesis continued to dominate health policy, and the call to reduce saturated fat became ingrained in public consciousness.